Antiviral mechanism of polyanionic carbosilane dendrimers against HIV-1
نویسندگان
چکیده
منابع مشابه
Antiviral mechanism of polyanionic carbosilane dendrimers against HIV-1
Nanotechnology-derived platforms, such as dendrimers, are very attractive in several biological applications. In the case of human immunodeficiency virus (HIV) infection, polyanionic carbosilane dendrimers have shown great potential as antiviral agents in the development of novel microbicides to prevent the sexual transmission of HIV-1. In this work, we studied the mechanism of two sulfated and...
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Anionic carbosilane dendrimers of generations 1-3 have been synthesized containing carboxylate G(n)X(C(2)H(4)CO(2)Na)(m) and sulfonate G(n)X(C(2)H(4)SO(3)Na)(m) peripheral groups and derived from two different cores, 1,3,5-(HO)(3)C(6)H(3) (X = O(3)) and Si(C(3)H(5))(4) (X = Si). The peripheral anionic groups make these dendrimers water soluble, despite their highly hydrophobic framework. These ...
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ژورنال
عنوان ژورنال: International Journal of Nanomedicine
سال: 2016
ISSN: 1178-2013
DOI: 10.2147/ijn.s96352